Thursday, May 31, 2012

Marijuana Linked to Lower Mortality Rate for Patients with Psychotic Disorders

Source: National Institutes of Health
Conclusion: Overall five- (3.1% vs 7.5%) and ten-year mortality risk (5.5% vs. 13.6%) was lower in cannabis users than in non-users with psychotic disorders (p = 0.005) in a survival model. Alcohol use was not predictive of mortality. We observed a lower mortality risk in cannabis-using psychotic disorder patients compared to cannabis non-users despite subjects having similar symptoms and treatments. Future research is warranted to replicate these findings and to shed light on the anti-inflammatory properties of the endocannabinoid system and its role in decreased mortality in people with psychotic disorders.

Friday, April 13, 2012

Marijuana-like chemicals trigger receptors on human immune cells that can directly inhibit a type of human immunodeficiency virus (HIV) found in late-stage AIDS

Source: PLoS ONE
Conclusion: Our findings suggest that CB2R activation in CD4+ T cells can inhibit actin reorganization and impair productive infection following cell-free or cell-associated viral acquisition of CXCR4-tropic HIV-1 in resting cells. Therefore, the clinical use of CB2R agonists in the treatment of AIDS symptoms may also exert beneficial adjunctive antiviral effects against CXCR4-tropic viruses in late stages of HIV-1 infection.

Friday, March 9, 2012

Cannabinoid 2 receptors regulate impulsive behavior

Source: Neuroscience Institute of Alicante
Conclusion: Manipulating the endocannabinoid system can modulate high levels of impulsivity. This is the main problem in psychiatric illnesses such a schizophrenia, bipolar disorder and substance abuse.

Wednesday, March 7, 2012

Prenatal Marijuana Exposure and Neonatal Outcomes in Jamaica: An Ethnographic Study

Source: American Academy of Pediatrics
Conclusion: The absence of any differences between the exposed on nonexposed groups in the early neonatal period suggest that the better scores of exposed neonates at 1 month are traceable to the cultural positioning and social and economic characteristics of mothers using marijuana that select for the use of marijuana but also promote neonatal development.

Cannabinergic Pain Medicine: A Concise Clinical Primer and Survey of Randomized-controlled Trial Results

Source: National Institutes of Health
Conclusion: Of the 56 hits generated, 38 published RCTs (randomized-controlled trial) met the survey criteria. Of these, 71% (27) concluded that cannabinoids had empirically demonstrable and statistically significant pain-relieving effects, whereas 29% (11) did not.

Association Between Marijuana Exposure and Pulmonary Function Over 20 Years

Source: Journal of the American Medical Association
Conclusion: Occasional and low cumulative marijuana use was not associated with adverse effects on pulmonary function.